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Micro-Satellite Instability (MSI)-High Cancers: How and When to Test your Patients
MSI-HIgh cancers are characterized by one or more deleted mismatch repair (d-MMR) proteins MLH1, MSH2, MSH6, and PMS2. Germline (inherited) or somatic (tumor-specific) DNA changes result in loss of these proteins, and either the tumor DNA or tumor cells can be tested to identify MSI-High cancers.