What's Happening at PPLS? Archives - Page 3 of 7 - Precision Pathology

Precision Pathology Services Presents MSI-High Cancer Testing

Micro-Satellite Instability (MSI)-High Cancers: How and When to Test your Patients

MSI-HIgh cancers are characterized by one or more deleted mismatch repair (d-MMR) proteins MLH1, MSH2, MSH6, and PMS2.  Germline (inherited) or somatic (tumor-specific) DNA changes result in loss of these proteins, and either the tumor DNA or tumor cells can be tested to identify MSI-High cancers.